Relating the cortical visual contrast gain response to spectroscopy-measured excitatory and inhibitory metabolites in people who experience migraine

YM Chan; R Glarin; BA Moffat; S Bode; AM McKendrick

Journal article

Relating the cortical visual contrast gain response to spectroscopy-measured excitatory and inhibitory metabolites in people who experience migraine

YM Chan, R Glarin, BA Moffat, S Bode, AM McKendrick

Plos One | PUBLIC LIBRARY SCIENCE | Published : 2022

DOI: 10.1371/journal.pone.0266130

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Abstract

Objective This study aimed to determine whether the visual response to flickering checkerboard patterns measured using electroencephalography (EEG) relate to excitatory or inhibitory metabolite levels measured using ultra-high (7Tesla/7T) magnetic resonance spectroscopy (MRS). Background Electrophysiological studies have shown altered visual cortical response amplitudes and contrast gain responses to high contrast flickering patterns in people with migraine. These contrast response anomalies have been argued to represent an imbalance between cortical inhibition and excitation, however the specific mechanism has not been elucidated. Methods MRS-measured metabolite levels were obtained from th..

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University of Melbourne Researchers

Rebecca Glarin Author

Bradford Moffat Author

Allison McKendrick Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

NHMRC Project Grant APP1081874 (https://www.nhmrc.gov.au/) (AMM) The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. ARC Discovery Project Grant DP140100157 (https://www.arc.gov.au/)(AMM) The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Kenneth Richard Styles Research Fund (https://www.unimelb.edu.au/__data/assets/pdf_file/0005/1793696/utr7288.pdf) (AMM) The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.